Goodpasture Syndrome

What is Goodpasture syndrome?

4 min readJul 30, 2021


Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in the lungs and kidneys, leading to bleeding from the lungs and kidney failure.
Usually, the immune system makes antibodies to fight off germs. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys. It can be fatal if not quickly diagnosed and treated.

Photo by National Cancer Institute on Unsplash

What are the causes?

Medical experts are not sure what causes this disease. It can run in families, so that genetics may play a role. The condition may occur because of a combination of other factors.

Factors that may increase the risk of Goodpasture syndrome include:
- Exposure to certain chemicals, such as hydrocarbon solvents and the weedkiller paraquat
- Exposure to metallic dust
- Use of certain drugs, such as cocaine
- Tobacco smoking
- Viral infections

This disease most often occurs in people ages 20 to 30 or those older than age 60. It is more common in men. In some cases, bleeding in the lungs may occur. In most cases, this disease does not cause lasting damage to the lungs. But kidney damage may be long-lasting. If the kidneys fail, a kidney transplant or dialysis may be needed.

What are the symptoms of Goodpasture syndrome?

These are the most common symptoms of Goodpasture syndrome:
- Lack of energy or tiring quickly (fatigue)
- Nausea
- Trouble breathing
- Pale skin

As the condition progresses, other symptoms may occur, including:

- Coughing up blood
- Burning feeling when urinating
Over time, symptoms of kidney involvement may occur, including:
- Small amounts of blood in the urine (hematuria)
- Protein in the urine (proteinuria)
Although Goodpasture syndrome may cause life-threatening bleeding in the lungs, it usually…




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